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100+ results found
  1. O-linked glycosylation of mucins

    • reactome.org
  2. a

    The significance of glycosylation on the function of the calcium-sensing...

    • researchdata.ands.org.au
    Published Sep 20, 2012
  3. Data from: Diseases of glycosylation

    • reactome.org
  4. R

    N-linked glycosylation of WNTs

    • reactome.org
  5. R

    Glycosylation of Hh

    • reactome.org
  6. Diseases associated with O-glycosylation of proteins

    • reactome.org
  7. f

    Data from: Comprehensive Analysis of Protein N‑Glycosylation Sites by...

    • figshare.com
    Updated Feb 18, 2016
  8. a

    Data from: Characterization of the glycosylation on recombinant human...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  9. f

    Data from: Deciphering Protein O‑Glycosylation: Solid-Phase Chemoenzymatic...

    • figshare.com
    Updated Jun 24, 2018
  10. o

    Data from: Topological N-glycosylation and site-specific N-glycan sulfation...

    • www.omicsdi.org
  11. f

    Data from: Murine Plasma N‑Glycosylation Traits Associated with Sex and...

    • figshare.com
    Updated Oct 3, 2016
  12. a

    The glycosylation and structure of human serum IgA1, Fab, and Fc regions and...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  13. a

    Data from: N-glycosylation of horseradish peroxidase from cell culture.

    • researchdata.ands.org.au
    Published Jun 26, 2012
  14. o

    Glycosylation change in mouse CD8 T cells during development

    • www.omicsdi.org
  15. a

    Data from: Separation and characterization of the two Asn-linked...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  16. a

    Data from: Unusual N-glycosylation of a recombinant human erythropoietin...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  17. f

    Data from: Detecting Proteins Glycosylation by a Homogeneous Reaction System...

    • figshare.com
    Updated Mar 28, 2017
  18. MOESM1 of N-glycosylation proteome enrichment analysis in kidney reveals...

    • figshare.com
    Updated Dec 15, 2016
  19. f

    Data from: Comparative Proteomics and Glycoproteomics Reveal Increased...

    • figshare.com
    Updated Feb 16, 2016
  20. O-glycosylation of TSR domain-containing proteins

    • reactome.org
  21. e

    Identification of genes involved in congenital disorders of glycosylation...

    • ega-archive.org
  22. o

    To identify glycosylation-specific targets contributing to the interferon...

    • www.omicsdi.org
    • datamed.ucsd.edu
  23. MOESM2 of Mass spectrometry-based analyses showing the effects of secretor...

    • figshare.com
    Updated Dec 14, 2016
  24. MOESM2 of Mapping N-linked glycosylation of carbohydrate-active enzymes in...

    • figshare.com
    Updated Dec 14, 2016
  25. Data_Sheet_1_N-Glycosylation Regulates the Trafficking and Surface Mobility...

    • figshare.com
    Updated Jun 4, 2018
  26. a

    Data from: O- and N-glycosylation of the Leishmania mexicana-secreted acid...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  27. d

    The use of the glycoarray chip to investigate VHL-dependent protein...

    • datamed.org
    • datamed.ucsd.edu
    • +2more
  28. f

    Data from: A New Method for the Rapid Diagnosis of Protein N‑linked...

    • figshare.com
    Updated Feb 19, 2016
  29. o

    Identification and Quantification of Site-Specific N-Glycosylation in Human...

    • www.omicsdi.org
  30. s

    GlySeq

    • scicrunch.org
  31. s

    PTMcode

    • scicrunch.org
  32. o

    To investigate how the glycosylation of podocyte proteins changes during...

    • www.omicsdi.org
  33. o

    Deconstruction of protein O-glycosylation

    • www.omicsdi.org
  34. a

    ALG12

    • www.alliancegenome.org
    Updated Feb 18, 2019
  35. a

    Data from: Novel N-glycosylation in eukaryotes: laminin contains the linkage...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  36. a

    Data from: The conformational effects of N-glycosylation on the tailpiece...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  37. MOESM7 of Mass spectrometry-based analyses showing the effects of secretor...

    • search.datacite.org
    • figshare.com
    Updated Dec 14, 2016
  38. O-linked glycosylation

    • reactome.org
  39. f

    Data from: Mapping N-Linked Glycosylation Sites in the Secretome and Whole...

    • figshare.com
    Updated Feb 22, 2016
  40. f

    Data from: Specific and Nonspecific Effects of Glycosylation

    • figshare.com
    Updated Feb 20, 2016
  41. s

    ProGlycProt

    • scicrunch.org
  42. Dataset pertaining to the publication “Polymorphisms in B3GAT1, SLC9A9 and...

    • datashare.is.ed.ac.uk
    Published Jul 3, 2017
  43. f

    Data from: Organocatalyzed Direct Glycosylation of Unprotected and...

    • figshare.com
    Updated Feb 18, 2016
  44. a

    TMEM165

    • www.alliancegenome.org
    Updated Feb 18, 2019
  45. a

    Data from: Drastic differences in glycosylation of related S-layer...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  46. u

    The role of glycans and glycosylation in cell-type specific effects on viral...

    • datamed.ucsd.edu
    Updated Jun 2, 2014
  47. o

    Data from: Detecting Proteins Glycosylation by a Homogeneous Reac-tion...

    • www.omicsdi.org
  48. o

    Irani2015 - Genome-scale metabolic model of P.pastoris N-glycosylation

    • www.omicsdi.org
  49. u

    Pilot project to determine optimal bioreactor protein glycosylation...

    • datamed.ucsd.edu
  50. a

    GALNT13

    • www.alliancegenome.org
    Updated Feb 18, 2019
  51. m

    Galnt1

    • rgd.mcw.edu
  52. u

    Coordinate Regulation of Metabolites Glycosylation and Stress Hormones...

    • datamed.ucsd.edu
  53. f

    Data from: Evaluation of Different N‑Glycopeptide Enrichment Methods for...

    • figshare.com
    Updated Aug 29, 2016
  54. i

    Data from: Influences of glycosylation on antigenicity, immunogenicity, and...

    • www.immunedata.org
  55. o

    Deconstruction of O-glycosylation – Polypeptide GalNAc-T Isoforms...

    • www.omicsdi.org
  56. R

    Glycosylation of mouse WNTs

    • reactome.org
  57. u

    Deconstruction of O-glycosylation – Polypeptide GalNAc-T Isoforms...

    • datamed.ucsd.edu
    • www.omicsdi.org
    Updated Sep 10, 2015
  58. d

    Data from: Generation of a monoclonal antibody recognizing the heavily...

    • datadryad.org
    Published Feb 14, 2018
  59. a

    Data from: Characterization of the glycosylation sites in cyclooxygenase-2...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  60. Quantification of the N-glycosylation site occupancy.

    • figshare.com
    Updated Dec 3, 2015
  61. a

    Data from: Glycosylation pattern and processing of envelope gene products...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  62. o

    To understand how glycosylation on human B cells is regulated during...

    • www.omicsdi.org
  63. u

    Expression data from Congenital disorders of Glycosylation type-1 patients...

    • datamed.ucsd.edu
  64. a

    Control of IgG/Fc glycosylation: a comparison of oligosaccharides from...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  65. R

    Glycosylation of Pre-Notch by Fringe

    • reactome.org
  66. a

    Data from: O-linked glycosylation of rat renal gamma-glutamyltranspeptidase...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  67. f

    Data from: Analysis of Congenital Disorder of Glycosylation-Id in a Yeast...

    • acs.figshare.com
    Updated Feb 20, 2016
  68. R

    O-linked glycosylation

    • reactome.org
  69. u

    Elucidating mechanisms by which regulated expression of proteoglycans and...

    • datamed.ucsd.edu
  70. Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)

    • reactome.org
  71. s

    GlyVicinity

    • scicrunch.org
  72. o

    Glycosylation of the HA protein of H5N1 virus increases its virulence in...

    • www.omicsdi.org
  73. m

    Mgat2

    • rgd.mcw.edu
  74. a

    TMEM115

    • www.alliancegenome.org
    Updated Feb 18, 2019
  75. u

    To define the role of glycosylation in the interaction and metastatic...

    • datamed.ucsd.edu
  76. a

    ST6GALNAC1

    • www.alliancegenome.org
    Updated Feb 18, 2019
  77. f

    Data from: Proteome-Wide Analysis of N‑Glycosylation Stoichiometry Using...

    • acs.figshare.com
    Updated Sep 15, 2017
  78. R

    Glycosylation of ENV polyprotein

    • reactome.org
  79. a

    Data from: Microheterogeneity of N-glycosylation on a stylar...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  80. R

    Glycosylation and Folding of HA

    • reactome.org
  81. R

    Glycosylation of Pre-NOTCH by FRINGE

    • reactome.org
  82. a

    Data from: Glycosylation sites and site-specific glycosylation in human...

    • researchdata.ands.org.au
    Published Jun 26, 2012
  83. Supplementary Material for: Glucocorticoids Reduce Aberrant O-Glycosylation...

    • karger.figshare.com
    Updated Mar 12, 2018
  84. o

    Data from: N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals...

    • www.omicsdi.org
  85. o

    N-glycoproteomic analyses from different insect species reveal conserved and...

    • www.omicsdi.org
  86. m

    STT3A

    • rgd.mcw.edu
  87. o

    Data from: Integrated proteomic and N-glycoproteomic analyses of doxorubicin...

    • www.omicsdi.org
  88. f

    Data from: Targeted Mass Spectrometry Approach Enabled Discovery of...

    • figshare.com
    Updated Aug 7, 2017
  89. f

    Data from: Changes in Healthy Human IgG Fc-Glycosylation after Birth and...

    • figshare.com
    Updated May 27, 2016
  90. o

    TAILS N-Terminomics and Proteomics Show Complex Regulation of Proteolytic...

    • www.omicsdi.org
  91. a

    Glycosylation pattern of human inter-alpha-inhibitor heavy chains.

    • researchdata.ands.org.au
    Published Jun 26, 2012
  92. R

    O-linked glycosylation of mucins

    • reactome.org
  93. f

    Data from: o‑(p‑Methoxyphenylethynyl)phenyl Glycosides: Versatile New...

    • figshare.com
    Updated Sep 1, 2017
  94. m

    Galnt1

    • rgd.mcw.edu
  95. u

    Pancreatic tumor cell lines

    • datamed.ucsd.edu
    • www.omicsdi.org
    Updated Nov 27, 2011
  96. R

    Asparagine N-linked glycosylation

    • reactome.org
  97. Summary of α-DG glycosylation as assessed by flow cytometry in 21 patient...

    • plos.figshare.com
    Updated Dec 2, 2015
  98. f

    Data from: Integrity of Glycosylation Processing of a...

    • figshare.com
    Updated Feb 8, 2018
  99. o

    Cystinosin turnover

    • www.omicsdi.org
  100. a

    St3gal1

    • www.alliancegenome.org
    Updated Feb 20, 2019
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O-linked glycosylation of mucins

37 scholarly articles cite this dataset (View in Google Scholar)
Dataset provided by
European Bioinformatics Institutehttp://www.ebi.ac.uk/
Authors
Bijay Jassal
Available download formats from providers
sbgn, pdf, biopax2, biopax3, owl, sbml, docx
Description

Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. To date, there are approximately 20 genes that express mucins. Mature mucins are composed of two distinct regions:
(1) The amino- and carboxy-terminal regions are very lightly glycosylated, but rich in cysteines. The cysteine residues participate in establishing disulfide linkages within and among mucin monomers.
(2) A large central region rich in serine, threonine and proline residues called the variable number of tandem repeat (VNTR) region which can become heavily O-glycosylated with hundreds of O-GalNAc glycans.
N-acetyl-galactosamine (GalNAc) is the first glycan to be attached, forming the simplest mucin O-glycan. After this, several different pathways are possible generating "core" structures. Four core structures are commonly formed, several others are possible but infrequent. O-linked glycans are often capped by the addition of a sialic acid residue, terminating the addition of any more O-glycans (Brockhausen et al, 2009; Tarp and Clausen, 2008).

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