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67 datasets found
  1. f

    Cue Reactivity Is Associated with Duration and Severity of Alcohol...

    • figshare.com
    tiff
    Updated May 31, 2023
  2. o

    Data from: Conflict anticipation in alcohol dependence - A model-based fMRI...

    • omicsdi.org
    Updated Jul 13, 2023
  3. f

    Table_1_Response Inhibition and Binge Drinking During Transition to...

    • figshare.com
    docx
    Updated Jun 1, 2023
  4. o

    Data from: FMRI-based prediction of naltrexone response in alcohol use...

    • omicsdi.org
    xml
    Updated Mar 2, 2024
  5. d

    Exenatide once weekly for alcohol use disorder investigated in a randomized,...

    • b2find.dkrz.de
    Updated Sep 18, 2022
    + more versions
  6. N

    Data from: Acute alcohol administration dampens central extended amygdala...

    • neurovault.org
    zip
    Updated Nov 20, 2018
  7. N

    Acute alcohol administration dampens central extended amygdala reactivity:...

    • neurovault.org
    nifti
    Updated Nov 20, 2018
    + more versions
  8. f

    Data_Sheet_1_Right Inferior Frontal Activation During Alcohol-Specific...

    • figshare.com
    pdf
    Updated Jun 4, 2023
  9. N

    Data from: Mindful attention to alcohol can reduce cravings in the moment...

    • neurovault.org
    zip
    Updated Jul 27, 2023
  10. d

    Data from: Alcoholism gender differences in brain responsivity to emotional...

    • b2find.dkrz.de
    Updated Oct 21, 2023
    + more versions
  11. d

    Data from: Alcoholism gender differences in brain responsivity to emotional...

    • datadryad.org
    • zenodo.org
    zip
    Updated Apr 30, 2019
    + more versions
  12. o

    Data from: A polymorphism in GABRA2 is associated with the medial frontal...

    • omicsdi.org
    xml
    Updated Dec 15, 2010
  13. o

    Data from: High versus low level of response to alcohol: evidence of...

    • omicsdi.org
    Updated Jan 1, 2013
  14. o

    Data from: Dynamic frontostriatal functional peak connectivity (in alcohol...

    • omicsdi.org
    Updated Jan 1, 2015
  15. P

    NCANDA Dataset

    • paperswithcode.com
    Updated Sep 22, 2021
  16. f

    What Can the Brain Teach Us about Winemaking? An fMRI Study of Alcohol Level...

    • figshare.com
    docx
    Updated May 30, 2023
  17. N

    Nucleus accumbens connectivity at rest is associated with alcohol...

    • neurovault.org
    nifti
    Updated Mar 5, 2018
  18. o

    Resting State fMRI Functional Connectivity in Cocaine Dependence

    • osf.io
    Updated Mar 8, 2022
  19. N

    Exploring variability in basal ganglia connectivity with functional MRI in...

    • neurovault.org
    nifti
    Updated Jun 30, 2018
  20. o

    Data from: Insula Sensitivity to Unfairness in Alcohol Use Disorder.

    • omicsdi.org
    Updated Jan 1, 2017
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Zsuzsika Sjoerds; Wim van den Brink; Aartjan T. F. Beekman; Brenda W. J. H. Penninx; Dick J. Veltman (2023). Cue Reactivity Is Associated with Duration and Severity of Alcohol Dependence: An fMRI Study [Dataset]. http://doi.org/10.1371/journal.pone.0084560

Cue Reactivity Is Associated with Duration and Severity of Alcohol Dependence: An fMRI Study

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36 scholarly articles cite this dataset (View in Google Scholar)
tiffAvailable download formats
Dataset updated
May 31, 2023
Dataset provided by
PLOS ONE
Authors
Zsuzsika Sjoerds; Wim van den Brink; Aartjan T. F. Beekman; Brenda W. J. H. Penninx; Dick J. Veltman
License

Attribution 4.0 (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/
License information was derived automatically

Description

IntroductionWith the progression of substance dependence, drug cue-related brain activation is thought to shift from motivational towards habit pathways. However, a direct association between cue-induced brain activation and dependence duration has not yet been shown. We therefore examined the relationship between alcohol cue-reactivity in the brain, cue-induced subjective craving and alcohol dependence duration and severity. Since alcohol dependence is highly comorbid with depression/anxiety, which may modulate brain responses to alcohol cues, we also examined the relation between comorbid depression/anxiety and cue-reactivity.MethodsWe compared 30 alcohol dependent patients with 15 healthy controls and 15 depression/anxiety patients during a visual alcohol cue-reactivity task using functional magnetic resonance imaging blood oxygenated level-dependent responses and subjective craving as outcomes. Within the alcohol dependent group we correlated cue-reactivity with alcohol dependence severity and duration, with cue-induced craving and with depression/anxiety levels.ResultsAlcohol dependent patients showed greater cue-reactivity in motivational brain pathways and stronger subjective craving than depression/anxiety patients and healthy controls. Depression/anxiety was not associated with cue-reactivity, but depression severity in alcohol dependent patients was positively associated with craving. Within alcohol dependence, longer duration of alcohol dependence was associated with stronger cue-related activation of the posterior putamen, a structure involved in habits, whereas higher alcohol dependence severity was associated with lower cue-reactivity in the anterior putamen, an area implicated in goal-directed behavior preceding habit formation.ConclusionCue-reactivity in alcohol dependence is not modulated by comorbid depression or anxiety. More importantly, the current data confirm the hypothesis of a ventral to dorsal striatal shift of learning processes with longer dependence duration, which could underlie increasingly habitual substance use with progressing substance dependence.

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